Letter regarding Shen et al. entitled “The APE1 Asp148Glu polymorphism and colorectal cancer susceptibility: a meta-analysis”

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NQO1 C609T polymorphism and colorectal cancer susceptibility: a meta-analysis

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Effect of APE1 T2197G (Asp148Glu) Polymorphism on APE1, XRCC1, PARP1 and OGG1 Expression in Patients with Colorectal Cancer

It has been hypothesized that genetic variation in base excision repair (BER) might modify colorectal adenoma risk. Thus, we evaluated the influence of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in normal and tumor samples from patients with colorectal cancer. The results indicate a downregulation of OGG1 and an upregulation of XRCC1 expression in tumor tissu...

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Association of APE1 Gene Asp148Glu Variant with Digestive Cancer: A Meta-Analysis

BACKGROUND Apurinic/apyrimidinic endonuclease-1 (APE1) is a rate-limiting enzyme in DNA base excision repair and has been implicated in carcinogenesis. In this study, we summarize available data to examine the susceptibility of APE1 gene Asp148Glu variant to digestive cancer via a meta-analysis. MATERIAL AND METHODS Study selection and data abstraction were conducted independently by 2 author...

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ژورنال

عنوان ژورنال: Tumor Biology

سال: 2014

ISSN: 1010-4283,1423-0380

DOI: 10.1007/s13277-014-2804-1